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ACTH (Adrenocorticotropic Hormone) is a hormone produced by the pituitary gland that stimulates the adrenal glands to release cortisol, a key hormone involved in the body’s response to stress, metabolism, immune function, and regulation of blood sugar levels.

The ACTH test measures the levels of this hormone in the blood and is commonly used to evaluate the function of the adrenal glands and the pituitary gland. It helps diagnose conditions such as:

• Addison’s disease (low cortisol production due to insufficient ACTH or adrenal dysfunction).
• Cushing's syndrome (high cortisol levels, often due to excessive ACTH or adrenal tumors).
• Pituitary disorders affecting ACTH production.

ACTH levels follow a daily rhythm and typically peak in the early morning and fall at night, which is why the timing of the test is important.