Thyroid antibody testing is primarily used to diagnose autoimmune thyroid diseases and differentiate them from other types of thyroiditis. It can be ordered to investigate the cause of an enlarged thyroid gland (goiter) and to follow up on abnormal thyroid function test results (such as T3, T4, and TSH).
Mild to moderately elevated levels of thyroid antibodies can be found in a variety of thyroid and autoimmune disorders, including thyroid cancer, Type 1 diabetes, rheumatoid arthritis, pernicious anemia, and autoimmune collagen vascular diseases. Significantly increased levels are more commonly associated with autoimmune thyroid diseases like Hashimoto’s thyroiditis (hypothyroidism) and Graves’ disease (hyperthyroidism).
The presence of these antibodies in a pregnant woman can increase the risk of thyroid dysfunction (either hypothyroidism or hyperthyroidism) in the fetus or newborn.
AMA, also known as Anti-Microsomal Antibodies, TPO (Anti-thyroperoxidase), or Anti-TPO, are common markers tested in these conditions.