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An increase in CA 15.3 levels is commonly associated with certain types of breast cancer, as well as lung cancer and some non-cancerous conditions. This test is particularly useful for monitoring therapy and assessing prognosis in patients diagnosed with malignant tumors.

After treatment, CA 15.3 levels typically decrease, signaling a positive response to therapy. Conversely, an increase in CA 15.3 may indicate relapse, residual disease, or the presence of metastasis. Therefore, the CA 15.3 test serves as an important tool for evaluating the evolution of the tumor and tracking the effectiveness of treatment. A rise in levels often suggests tumor progression and a poor response to therapy, while a decrease may reflect successful treatment and a favorable outcome.