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SHBG (Sex Hormone-Binding Globulin) is a protein produced by the liver that binds to sex hormones like testosterone, estrogen, and dihydrotestosterone (DHT) in the bloodstream, regulating their bioavailability and activity in tissues.

The SHBG test measures the amount of SHBG in the blood and helps assess hormonal balance. It is often used to:

• Evaluate androgen levels in conditions like PCOS (Polycystic Ovary Syndrome), where SHBG may be low and free testosterone is elevated.
• Assess testosterone levels in both men and women, as low SHBG can lead to higher levels of free testosterone, affecting conditions like hirsutism (excessive hair growth in women).
• Help diagnose liver diseases or thyroid disorders, as SHBG levels can be affected by these conditions.

SHBG levels can be influenced by factors like age, sex, body weight, and hormonal changes, making it a useful marker in evaluating overall endocrine health.