When evaluating patients with signs and symptoms of an autoimmune tissue disease and a positive test for antinuclear antibodies (ANA), it's important to consider the presence of specific autoantibodies such as SS-A (Ro) and SS-B (La). These antibodies are commonly associated with several autoimmune conditions:
SS-A (Ro): Also known as Ro, this antigen is primarily associated with Sjogren's syndrome, where antibodies against SS-A are found in 40-95% of cases. They are also present in Systemic Lupus Erythematosus (SLE) in 20-60% of cases, primary biliary cirrhosis (around 20%), and occasionally in chronic active hepatitis.
SS-B (La): Known as La, this antigen is most often found in women (with a ratio of 29:1) and is strongly associated with Sjogren's syndrome (40-95%) and SLE (10-20%).
The presence of these antibodies can help in diagnosing autoimmune diseases like Sjogren's syndrome and SLE and assist in determining the appropriate course of treatment.
Test Type:
Blood
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Fasting:
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